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MicroVolt T
Wave Alternans (MTWA) Risk Assessment of
Malignant Arrhythmias (introduction)
European News
Web Page
Editor: D. Marangoni Updated September 1st, 2010
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MTWA at 2010 European
Congress of Cardiology
ESC important abstract on Pacing
modes
Shocking
revelations at the HRS
(thats
why it is better to select the ICD patients)
MTWA HRS 2010
Denver presentations
(Circ Arrhythm
Electrophysiol.
2009;2:686-694.)
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Risk
stratification for sudden cardiac death: Is there a clinical role
for T wave alternans? (EXTRACT Heart Rhythm
2009;6:S56 S61) Circulation (July 21st) Correspondence
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Letter
by De Ferrari and Verrier Regarding Article, "Role of Microvolt T-Wave
Alternans in Assessment of Arrhythmia Vulnerability Among Patients With Heart
Failure and Systolic Dysfunction: Primary Results From the T-Wave Alternans Sudden
Cardiac Death in Heart Failure Trial Substudy"
MTWA at the
European Congress of Cardiology in Barcelona (August 31- Sept 1st)
Last issues:
US registry
points to substantial risk from ICD, pacemaker replacement
TWA
Presentations at HRS 2009 in Boston
Can we alternate between T-wave
alternans testing methods?
Heart
Rhythm, Vol 6, No 3, March 2009
Yale
University investigated whether anger-induced MTWA was associated with risk of
arrhythmic events (Jacc March 2009)
February 2009:
Podcast posted on the Heart Rhythm Journals website: Dr. Zipes,
editor of the journal, interviews Dr. Rosenbaum about T wave alternans topics include his take on the
MASTER trial and how he uses MTWA in clinical practice:
Click to Listen http://www.heartrhythmjournal.com/webfiles/images/journals/hrthm/Feb09_David_Rosenbaum_Interview.mp3
From JACC: ABCD
trial T-wave alternans to improve sudden cardiac death prevention.
Watch a related CVN
video. 
2008
SCD-Heft
Substudy review paper published in Circulation Nov 11, Full free on line
SCD-HeFT Substudy Review
Summary
SCD-Heft Substudy and MASTER published
Comments from
D. Rosenbaum , P.Chan and T. Chow
NEW : Potentially life-threatening VA (cycle length ≤260
ms) that resulted in appropriate ICD therapy are found to be more than 3 times
the number of appropriate standard ICD Theraphy (J Cardiovasc Electrophysiol. 2008).
ICD therapy used again
as end point in SCD-Heft Substudy? but if
Dr Epstein AE, Principal Author of
ACC/AHA/HRS2008 Guidelines for Device-Based Therapy of Cardiac Rhythm
Abnormalities wrote in JACC October 2008 : The fact that ICD therapy is
not a surrogate for resuscitation from cardiac arrest is not new information
(NASPE 93)
Biventricular
pacing does not affect microvolt T-wave alternans in heart failure patients (Heart
Rhythm 2008 ): it can be used before CRT implant.
AHA/ACC/HRS
Scientific Statement on Noninvasive Risk Stratification Techniques for
Identifying Patients at Risk for Sudden Cardiac Death (Circulation.
2008;118:1497-1518.) : MTWA still the best method after EF
Review
paper from Dr Theodore Chow( PI of Master Study)
Expert Commentary from
T Chow paper
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For
additional information: |
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ACC/AHA/ESC
Guidelines for the Management of Patients with Ventricular Arrhythmias and
the Prevention of Cardiac Death Extracted Sections on T Wave Alternans in Class 2a (Level of
Evidence A): All reference papers are based on the Spectral Analytic Method |
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Additional Info on T Wave Alternans products : http://www.cambridgeheart.com
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