©© www.alternans.org
MicroVolt T
Wave Alternans (MTWA) Risk Assessment of Malignant
Arrhythmias (introduction)
European News
Web Page
Editor: D. Marangoni Updated January 24, 2012
..............
Faisal
M. Merchant and Antonis A. Armoundas ( Circulation 2012;125 539-549)
2011:
The ICD
Conversation: When to Implant,
. : a good opportunity to use TWA in the
decision ( Medscape Cardiology 2011)
with the
patient
Informed Consent (AMA)
Very Important
presentations at Venice Arrhythmias 2011:
·
Real
world money saving with MTWA application (abstract)
·
No
correlation between Mtwa Spectral method and MMA TWA(abstract).
T-wave
Alternans Testing in Pacemaker Patients
Comparison of Pacing Modes and Long-Term
Prognostic Relevance (5 years follow up) - Pacing and Clinical
Electrophysiology
The
Use of MTWA in the Detection of Ischemia
MTWA
Warns of Impending Cardiac Arrest (Diagnostic and Interventional
Cardiology - Oct 11)
Implementation
of ICD guidelines is difficult in European countries facing budget crunch
80% of
SCD in Women Could Be Avoided With All-Around Healthy Lifestyle - JAMA 2011; 306:62-69
( ICDs are not always necessary but risk
analysis is necessary)
Relationship
Between Early Diastolic Dysfunction and Abnormal Microvolt
T-Wave
Alternans in Patients with Type 2 Diabetes (Circulation I. March 2011)
Toward
More Optimal Use of Primary Prevention
Implantable
Cardioverter-Defibrillators (extracted from Circulation C. March 2011)
Irritable
Contemporary Risk of Implantable Cardioverter Defibrillators (
select
better your patients)
TWA
inside ICD (Circulation February 28, 2011)
Mechanisms
Underlying the Lack of Effect of Implantable Cardioverter-Defibrillator Therapy
on Mortality in High-Risk Patients With Recent Myocardial Infarction
Insights
from the Defibrillation in Acute Myocardial Infarction Trial (DINAMIT)
.. Select better your patients
..
Primary ICD implants may not
benefit seniors
...Thats why a better
stratification method is needed...
Ongoing
Clinical Trials on MTWA
MTWA at 2010
European Congress of Cardiology
ESC important abstract on
Pacing modes
Shocking
revelations at the HRS
(thats
why it is better to select the ICD patients)
MTWA HRS 2010
Denver presentations
(Circ Arrhythm Electrophysiol. 2009;2:686-694.)
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Risk
stratification for sudden cardiac death: Is there a clinical role
for T wave alternans? (EXTRACT Heart Rhythm
2009;6:S56 S61) Circulation (July 21st) Correspondence
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Letter by
De Ferrari and Verrier Regarding Article, "Role of Microvolt T-Wave
Alternans in Assessment of Arrhythmia Vulnerability Among Patients With Heart
Failure and Systolic Dysfunction: Primary Results From the T-Wave Alternans
Sudden Cardiac Death in Heart Failure Trial Substudy"
MTWA at the
European Congress of Cardiology in Barcelona (August 31- Sept 1st)
Last issues:
US registry
points to substantial risk from ICD, pacemaker replacement
TWA
Presentations at HRS 2009 in Boston
Can we alternate between T-wave
alternans testing methods?
Heart
Rhythm, Vol 6, No 3, March 2009
Yale University investigated
whether anger-induced MTWA was associated with risk of arrhythmic events
(Jacc March 2009)
February 2009:
Podcast
posted on the Heart Rhythm Journals website: Dr. Zipes, editor of the
journal, interviews Dr. Rosenbaum about T wave alternans
topics include his take on the MASTER trial and how
he uses MTWA in clinical practice:
Click to Listen http://www.heartrhythmjournal.com/webfiles/images/journals/hrthm/Feb09_David_Rosenbaum_Interview.mp3
From JACC: ABCD
trial T-wave alternans to improve sudden cardiac death prevention.
Watch a related CVN
video. 
2008
SCD-Heft
Substudy review paper published in Circulation Nov 11, Full free on line
SCD-HeFT Substudy Review
Summary
SCD-Heft Substudy and MASTER published
Comments from
D. Rosenbaum , P.Chan and T. Chow
NEW : Potentially life-threatening VA (cycle length ≤260
ms) that resulted in appropriate ICD therapy are found to be more than 3 times
the number of appropriate standard ICD Theraphy (J Cardiovasc Electrophysiol. 2008).
ICD therapy used again
as end point in SCD-Heft Substudy? but if
Dr Epstein AE, Principal Author of
ACC/AHA/HRS2008 Guidelines for Device-Based Therapy of Cardiac Rhythm
Abnormalities wrote in JACC October 2008 : The fact that ICD therapy is
not a surrogate for resuscitation from cardiac arrest is not new information
(NASPE 93)
Biventricular
pacing does not affect microvolt T-wave alternans in heart failure patients
(Heart Rhythm 2008 ): it can be used before CRT implant.
AHA/ACC/HRS
Scientific Statement on Noninvasive Risk Stratification Techniques for
Identifying Patients at Risk for Sudden Cardiac Death (Circulation.
2008;118:1497-1518.) : MTWA still the best method after EF
Review
paper from Dr Theodore Chow( PI of Master Study)
Expert Commentary from
T Chow paper
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For
additional information: |
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ACC/AHA/ESC
Guidelines for the Management of Patients with Ventricular Arrhythmias and
the Prevention of Cardiac Death Extracted Sections on T Wave Alternans in Class 2a (Level of
Evidence A): All reference papers are based on the Spectral Analytic Method |
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Additional Info on T Wave Alternans products : http://www.cambridgeheart.com
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